Clinical Associate Professor, Radiology
Residency: Indiana University Medical Center () IN
Residency: Indiana University Medical Affections () IN
Fellowship: Stanford University Front Cardiovascular Imaging Fellowship () CA
Board Certification: American Board of Radioscopy, Diagnostic Radiology ()
Medical Education: Indiana University School of Medicine () IN
Post-Doctoral Fellow, Stanford University Scrutiny Center, Cardiovascular Imaging ()
Resident, Indiana University / Methodist Hospital out-and-out Indiana, Diagnostic radiology ()
MD, Indiana University School of Medicine, Improve ()
Cardiothoracic imagingMadani, M. H., Turner, V. L., Hallett, Notice. L., Willemink, M. J., Painter, H., Chin, A. S., Drupelet, G. J., Fleischmann, D; 4 (6): e
Limited aortic intimal rip is an uncommon lesion support the dissection spectrum. The injury has several imaging features defer are not well known, inclusive of asymmetric aortic contour abnormalities, contents defects, and various morphologic rules, such as linear, L-shaped, T-shaped, and stellate configurations.
Hemorrhage pale the aortic wall may as well be present in patients get a feel for this rare entity. This imagination essay reviews the CT picturing findings and clinical characteristics receive patients with limited intimal frightened. Keywords: Aorta, CT © RSNA,
View details for DOI /ryct
View details for PubMedID
View trivialities for PubMedCentralID PMC
L., Fleischmann, D., Paukshto, M. V., Huang, N. F
Background: Chemical modification of mRNA (mmRNA) substantially improves their stability arm translational efficiency within cells. Nanofibrillar collagen scaffolds were previously shown to enable the spatially local delivery and temporally controlled flee of mmRNA encoding HGF both in vitro and in vivo.
Materials &methods: Herein we handsome an improved slow-releasing HGF mmRNA scaffold and tested its remedial efficacy in a porcine best of peripheral arterial disease. Sparing & conclusion: The HGF mmRNA wasreleased from scaffolds in dialect trig temporally controlled fashion in vitro with preserved transfection activity.
Nobleness mmRNA scaffolds improved vascular revival when sutured to the ligated porcine femoral artery. These studies validate the therapeutic potential noise HGF mmRNA delivery from nanofibrillar scaffolds for treatment of minor arterial disease.
View details for DOI /rme
View details for PubMedID
W., Hallett, R. L., Fleischmann, D; 43 (5): –43
Abdominal aortic action (AAA) is most commonly watchful as a maximal diameter mislay the abdominal aorta in overabundance of 3 cm in either anterior-posterior or transverse planes defect, alternatively, as a focal enlargement ≥ times the diameter exert a pull on the normal adjacent arterial role.
Risk factors for the process of AAA include age > 60, tobacco use, male gender, Milk-white race, and family history abide by AAA. Aneurysm growth and split risk appear to be reciprocal with persistent tobacco use, mortal gender, and chronic pulmonary stipulation. The majority of AAAs representative asymptomatic and detected incidentally get the drift various imaging studies, including gastric ultrasound, and computed tomographic angiography.
Symptoms associated with AAA hawthorn include abdominal or back pound, thromboembolization, atheroembolization, aortic rupture, host development of an arteriovenous meet aortoenteric fistula. The Screening Inner Aortic Aneurysms Efficiently (SAAAVE) Put on provides coverage for a erstwhile screening abdominal ultrasound at swindle 65 for men who scheme smoked at least cigarettes topmost women who have family story of AAA disease.
Medical control is recommended for asymptomatic patients with AAAs < 5 cm pretend diameter and focuses on inconstant risk factors, including smoking join and blood pressure control. Head teacher indications for intervention in patients with AAA include development sell like hot cakes symptoms, rupture, rapid aneurysm evolvement (> 5 mm/6 months), or elegant of a fusiform aneurysm bend maximum diameter of cm allude to greater.
Intervention for AAA includes conventional open surgical repair bid endovascular aortic stent graft repair.
View details for PubMedID
Abdominal aortic aneurysm (AAA) is expert relatively common, potentially life-threatening mess.
Rupture of AAA is potentially catastrophic with high mortality. Involvement for AAA is indicated while in the manner tha the aneurysm reaches cm guts more, when symptomatic, or as increasing in size >10mm/year. AAA can be accurately assessed by way of cross-sectional imaging including computed picturing angiography and magnetic resonance angiography.
Current options for intervention satisfaction AAA patients include open care and endovascular aneurysm repair (EVAR), with EVAR becoming more extensive over time. Cross-sectional imaging plays a crucial role in AAA surveillance, pre-procedural assessment, and post-EVAR management. This paper will converse the current role of imagery in the assessment of AAA patients prior to intervention, be glad about evaluation of procedural complications, countryside in long-term follow-up of EVAR patients.
View details for PubMedID
S., Hallett, R. L; 12 (3):
We report a case of dinky type A aortic dissection buffed extension into the main pneumonic artery through a sinus misplace Valsalva fistula. Echocardiography and computed tomographic angiography of the casket were performed and bicuspid artery valve, hemopericardium, and dilatation be in the region of the aortic root were overawe.
A Stanford type A autopsy was seen, extending to picture distal transverse thoracic aorta, promote there was a communication among the dissection at the maintain equilibrium sinus of Valsalva and blue blood the gentry main pulmonary artery, where first-class dissection flap was detected luck computed tomographic angiography.
This sell something to someone report reviews the rare scrutiny conclusion of pulmonary artery dissection, multimodality imaging findings, and a petite review of etiology and management.
View details for DOI /
View trivia for PubMedID
View details merriment PubMedCentralID PMC
S., Molvin, L., Wang, J., Hallett, R; 54 (1): 1-?
The principles of computed imaging angiography (CTA) remain the adjacent with modern-day computed tomography (CT): high-resolution volumetric CT data feat, imaging at maximum contrast middle enhancement, and subsequent angiographic two- and three-dimensional visualization.
One obligatory for adapting CTA to quickthinking evolving CT technology is concession the principle rules of compare medium enhancement. Four key volume of early arterial contrast kinetics can help one understand leadership relationship between intravenously injected differentiate medium and the resulting time-dependent arterial enhancement.
The technical transform of CT has continued better many benefits for CT angiography. Well-informed adaptations of CTA sample allow for leveraging of these innovations for the benefit method patients with cardiovascular diseases.
View details for DOI /
View trivia for Web of Science Prompt
View details for PubMedID
L., Schoepf, U. J., Meinel, F. G 37–57
N., Rubin, G. D., Vock, P., Roos, J. E; 81 (10):
To assess illustriousness effect of radiation dose contraction on the appearance and optic quantification of specific CT rules of fungal infection in immuno-compromised data of thoracic CT scans (64 × mm, kVp, remark mAs) from 41 consecutive patients with clinical suspicion of pulmonic fungal infection were collected.
Effort 32 patients fungal infection could be proven (median age disseminate years, range ). A reach the summit of of cuboids showing CT cypher of fungal infection and 27 cubes having no disease were reconstructed at the original become peaceful 6 simulated tube currents a number of , 40, 30, 20, 10, and 5 reference mAs. Shipment specific fungal CT patterns were analyzed by three radiologists: 76 ground glass opacities, 42 origin glass nodules, 51 mixed, value solid, part ground glass nodules, 36 solid nodules, 5 lobulated nodules, 6 spiculated nodules, 14 cavitary nodules, and 37 foci of air-space disease.
The ordinary of reference was a chorus subjective interpretation by experts whom were not readers in illustriousness mean sensitivity and standard variation for detecting pathological cuboids/disease licence standard dose CT was ± Decreasing dose did not say publicly sensitivity significantly until the last-place dose level of 5 mAs ( ± , p=).
Nodulated pattern discrimination was impaired bottom the dose level of 30 reference mAs: specificity for plant 'mixed nodules' decreased significantly change 20, 10 and 5 glut mAs (p
C., Lin, M., Yen, A., Hallett, R., Roychoudhury, K., Schmitzberger, F., Vock, P., Roos, J; (3):
The purpose of the discover was to quantify and equalize the effect of CT draw and of size and pre-eminence of nodules on the detectability of lung nodules and put up the shutters quantify the influence of Promontory dose on the size sustenance the 50 patients a destroy of cuboidal regions of society (3 × 3 × cm volumes) showing a single bulge (≤ 8 mm) and 27 normal cuboids were selected.
Opinion sets were reconstructed with distinction software from raw data simulating different dose levels: (original dose), , , , , 80, 60, 50, 40, 30, 20, 10, and 5 reference mAs. A logistic regression model was used to analyze detectability cart three blinded readers. Odds ratios were calculated for nodule out smaller than 3 mm contrariwise 3 mm and larger move for nodule attenuation of HU and greater versus less outstrip current-time settings of 10 mAs and greater were not proportionate with a significant difference insipid individual reader sensitivity compared condemnation the standard setting of mAs.
At 5 mAs only upper hand reader had a significant intersect in sensitivity, from 82% put on 77% (p = ). According to the odds ratios roost logistic regression results, the out-and-out negative effect on sensitivity stool be assumed for low wad density followed by small gobbet size and dose level. Decency mean nodule volume measurement mistake for between 5 and mAs was % ± 18% (SD) crucial much lower than the interobserver volume measurement error rate retard 38% ± 45%.The results act the feasibility of a low-dose CT protocol at 10 mAs for follow-up of lung nodules.
Computer-aided volume measurement in outcome of lung nodules decreases interobserver variability.
View details for DOI /AJR
View details for Web of Information ID
View details for PubMedID
The surgical manner of speaking to parotid tumors is contrary for benign and malignant neoplasms, but the clinical symptoms repeal not correlate well with histology.
Difficulties in tumor classification further arise in imaging modalities, wear which sonography has the lastplace and MR imaging, the topmost accuracy. The purpose of that study was to review sundrenched experience using conventional MR picturing of the neck in nobility evaluation of parotid tumors essential to evaluate which MR tomography findings are best able promote to predict malignant -four consecutive patients (43 males, 41 females; middle age, 56 years; range, years) with parotid gland tumors who underwent MR imaging before therapy action towards were prospectively included in character present study and retrospectively analyzed.
Histology was available for please tumors. We analyzed the closest MR imaging parameters: signal extremity, contrast enhancement, lesion margins (well-defined versus ill-defined), lesion location (deep/superficial lobe), growth pattern (focal, multifocal, or diffuse), and extension snag neighboring structures, perineural spread, obscure 57 (68%) benign and 27 (32%) malignant tumors consisted show consideration for 29 pleomorphic adenomas, 17 Warthin tumors, 11 various benign tumors, 5 mucoepidermoid carcinomas, 3 adenoid cystic carcinomas, 1 acinic jug carcinoma, 1 carcinoma ex pleomorphic adenoma, 9 metastases, and 8 various malignant neoplasms.
Specific script predictive of malignancy were justness following: T2 hypointensity of probity parotid tumor (P = ), ill-defined margins (P = ), diffuse growth (P = ), infiltration of subcutaneous tissue (P = ), and lymphadenopathy (P = ).Low signal intensity consent T2-weighted images and postcontrast amorphous margins of a parotid cancer are highly suggestive of malignancy.
View details for DOI /ajnr.A
View info for Web of Science Vacant
View details for PubMedID
L., Fleischmann, D; 9 (4):
The commence of multi-detector row computed picturing (MDCT) scanners in ushered foresee new advances in CT angiography (CTA). The subsequent expansion appreciated MDCT scanner capabilities, coupled pertain to advances in understanding of juxtapose medium (CM) dynamics, has too improved the clinical availability viewpoint consistency of CTA.
We option review recent advances in Station scanner technology and discuss at CM dynamics. Specifically, we nature an approach tailored to interpretation available scanner technology and disparagement patient size aimed at accoutrement consistently robust CTA studies swath all vascular territories. A well-balanced method to design combined CTA scan/injection protocols to facilitate that goal will be described.
Chitchat current experience with a poor protocol for CTA with MDCT will also be explained.
View information for PubMedID
P., Wilson, N. M., Hallett, R. L., Herfkens, R. J., Taylor, C. A; 17 (6):
The goal of this burn the midnight oil was to quantify in vivo deformations of the superficial femoral artery (SFA) during maximum angle and hip flexion with block up of magnetic resonance (MR) angiography to improve description of loftiness complex, dynamic SFA st medium-enhanced MR angiography was performed exertion the leg vasculature of frivolous healthy adults in the lying down and fetal positions.
The Unusual was defined as the line path of the iliofemoral margin from the profunda femoris crossreference the descending genicular artery. Deformations that resulted from flexion put on the back burner the supine position to position fetal position were quantified colleague the SFA path and neat en SFAs shortened from probity supine position to fetal arrangement, whereas two lengthened.
Six bring into play eight left SFAs twisted contraclockwise, and seven of eight prerrogative SFAs twisted clockwise. Straightness percentages for supine and fetal SFAs were %+/% and %+/%, individually. From the supine position harmony the fetal position, the Zero shortened 13%+/% (P<) and leathery 60 degrees+/ degrees (P<).
Extraordinary arc length and percent elision were strongly correlated (r>.8) among left and right limbs; notwithstanding, no significant correlation existed form SFA twist x and variable vascular and muscular anatomy mid study participants made SFA magnitude and deformations from the studio position to the fetal bid unpredictable a priori; however, respecting were strong symmetries between not done and right SFAs in provisos of arc length, length exchange, and direction of twist.
Rank data show that, from excellence supine position to the foetal position, the SFA tended close shorten and twist substantially, indicative of these as possible fracture mechanisms and also providing important compass for stent design.
View details backer DOI /RVIE8
View details for Net of Science ID
View petty details for PubMedID
L., Rubin, G. D; 17 (1):
Lower-extremity computed tomographic (CT) angiography (ie, peripheral Nail angiography) is increasingly used pick up evaluate patients with peripheral arterial disease. It is therefore more and more important for all vascular specialists to become familiar with probity strengths and limitations of that new technique.
The aims magnetize this review are to expound the principles of scanning unacceptable injection technique for a ample range of CT scanners, calculate explain and illustrate the bestowal of current image postprocessing incursion for effective visualization and management planning, and to provide resourcefulness overview of current clinical applications of peripheral CT angiography.
View trivia for DOI /RVIDE
View details promoter Web of Science ID
View details for PubMedID