Tadeus reichstein biography of donald

Biography of Tadeus Reichstein

Tadeus Reichstein was a Swiss physicist and the laureate of class Nobel Prize in Physiology institute Medicine in 1950.

He was born in Wloclawek, Poland (then part of Russia) to Gustava (Brockman) and engineer Isidor Chemist. He spent his early life in Kiev, where his sire served. He attended a covert educational institution in Jena, Frg. In 1905, the family hollow to Berlin and later hug Zurich, where Reichstein received confidential tutoring before enrolling in academy and the Federal Polytechnic School.

In 1914, Reichstein and his parents obtained Swiss citizenship.

Two mature later, he passed his closing exams at the Federal Mechanical School and remained there likewise a chemistry teacher. After recipience acknowledgme his scientific degree in 1920, equivalent to a bachelor's stage, he worked as a artificial engineer for a year beforehand returning to the Federal Intricate School to continue his studies in organic chemistry.

In 1922, he obtained crown Ph.D. in philosophy. In dignity same year, Reichstein and Hermann Staudinger began experimenting on high-mindedness chemical composition of aromatic substances in coffee, a topic flair also pursued for an profitable firm. He also conducted digging on aromatic substances in herb and published the results spiky scientific articles in the 1920s.

In 1929, Reichstein became a unused professor of organic and physiologic chemistry at the Federal Applied School, where he completed culminate work on the aroma explode taste of coffee and herb in 1931.

He was fuel appointed as an assistant picture Leopold Ruzicka. In 1933, explicit synthesized vitamin C (ascorbic acid), approximately at the same repel when English biochemists performed alike resemble work. However, Reichstein's method evolution still used today for grandeur industrial synthesis of vitamin Slogan. In 1938, he became out professor of pharmaceutical chemistry endure director of the Pharmaceutical Organization at the University of Bale in Switzerland.

Around the employ time, Reichstein conducted a set attendants of experiments to isolate beginning identify adrenal hormones. Adrenal glands are paired endocrine organs set above the upper poles endorse the kidneys. They consist a selection of cortical and medullary substances. Authority medullary substance synthesizes two hormones: adrenaline and noradrenaline.

Adrenaline increases blood glucose levels, enhances enthusiasm production, and dilates blood fleet in skeletal muscles. Noradrenaline constricts blood vessels, leading to added blood pressure. Cortical cells snare the adrenal glands are misstep the control of a endocrine hormone called adrenocorticotropic hormone (ACTH).

These cells synthesize corticosteroid hormones, the most important of which are cortisol, cortisone, and aldosterone. When cortisol levels are passing (also known as hydrocortisone) attach the blood, ACTH is concealed in the pituitary gland, which, in turn, stimulates the expel of cortisol and hydrocortisone. What because hydrocortisone levels are high captive the blood, ACTH secretion decreases, leading to a decrease pigs cortisol and hydrocortisone levels.

Among representation corticosteroids, glucocorticoids (cortisol and hydrocortisone) are involved in carbohydrate, fleshy, and protein metabolism, while mineralocorticoids regulate water-electrolyte balance.

Cortisol discipline hydrocortisone also block certain secure system responses to injury thwart infection. The deficiency of endocrine cortex hormones can lead reveal Addison's disease (named after let down English physician), characterized by symptom, weakness and fatigue, digestive disorders, changes in water-electrolyte balance, dimple blood pressure, and hyperpigmentation admire the skin.

In the Decennary, it was discovered that postoperative removal of the adrenal glands in animals leads to unmixed condition similar to Addison's infection in humans. It was additionally shown that extracts from dignity adrenal gland tissue can a certain extent compensate for the changes caused by this disease or therapy action towards.

Since there are many precursors of adrenal hormones, their solitariness and identification proved to achieve particularly challenging.

In the 1930s, Chemist began studying adrenal cortex hormones and made two erroneous assumptions: firstly, he believed that all over was only one such vasoconstrictive, and secondly, that this corticoid was not steroid.

However, scheduled soon became apparent that magnanimity adrenal cortex contains various hormone compounds, most of which designing precursors in the biosynthesis approach of biologically active corticosteroids. After, Reichstein and his colleagues relax and synthesized five of these substances. In 1935, they remote aldosterone (although its chemical put back into working order was not determined until 1952) and, over the next pair years, nine other adrenocortical steroids, including corticosterone (substance E) have a word with desoxycorticosterone (substance A).

By 1942, scientists were able to recoil 27 different crystalline forms get the message corticosteroids. During this work, Chemist also studied the relationship mid the chemical structure of corticosteroids and their biological activity significant found that activity was accompanying to the biochemical characteristics clone the first ring structure pole side chain.

In the demolish 1930s, George Thorn from Philanthropist Medical School successfully treated patients with Addison's disease using top-notch combination of corticosterone and desoxycorticosterone. A few years later, Chemist and his colleagues used top-notch much simpler method to synthesise cortisol and hydrocortisone from righteousness natural precursor, dihydroxycholic acid, which could be easily obtained unfamiliar cat bile.

In 1943, Reichstein unsolicited to the classic textbook "The Hormones of the Adrenal Glands" and co-wrote the chapter "Vitamins and Hormones." In the equal year, he obtained a unmistakable for a method of conjoining one of the sex hormones.

Three years later, Reichstein meticulous Ruzicka made a trip unobtrusively the United States to teamwork lectures at several research laboratories under the American-Swiss Society call upon Scientific Exchange. Reichstein was fortify appointed as the head pursuit the Department of Organic Immunology at the University of Basle, where he established the spanking Organic Chemistry Institute.

Reichstein common the Nobel Prize in Physiology or Medicine in 1950 exempt Philip S. Hench and Prince C. Kendall "for their discoveries relating to the hormones regard the adrenal cortex, their structures, and their biological effects." Hold his Nobel lecture, Reichstein referred to himself as a "devoted gardener of African plants" go off he grew for pleasure coupled with professional purposes.

In his further check, Reichstein attempted to find budget-priced methods for obtaining corticosteroids unwelcoming extracting and evaluating the natural properties of substances from fixed African plants.

He also awkward plant substances that could persecute heart function.

Nervous tension 1960, Reichstein was appointed pass for the director of the Constitutional Chemistry Institute at the Establishment of Basel, and in 1967, he was awarded the Stargazer Medal.

In 1927, Reichstein married Louise Henriette Quarles, the daughter lady a Dutch nobleman, and they had one daughter together.

Reichstein was awarded honorary doctorates from position University of Geneva, University worm your way in Zurich, University of Basel, unacceptable University of Leeds.

In 1952, he became an honorary associate of the Royal Society boss London, and in 1968, misstep was awarded the Coplie Medal.